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Research Associate, Next Gen Sequencing

Colossal Biosciences

Colossal Biosciences

Dallas, TX, USA
Posted on Nov 21, 2025

The Research Associate will take on large-scale genome sequencing initiatives for species conservation and de-extinction. They will expand on tools and methodologies to optimize sequencing data flow while maintaining and enhancing workflows to track samples from submission to data delivery.

This position is based on-site in Dallas, TX. Relocation assistance is available.

Duties and Responsibilities:

  • Prepare samples and perform high-throughput targeted amplicon sequencing workflows
  • Improve the state of the art of NGS for genome editing and genotyping
  • Utilize and adapt robotic automation for NGS workflows (Firefly Plus)
  • Maintain a working inventory for the sequencing core
  • Maintain a thorough and detailed electronic lab notebook
  • Maintain a clean and organized laboratory space

Required Skills and Abilities:

  • Capable of working in a fast-paced, high volume sequencing core on parallel projects, while maintaining accuracy and timely data transfer
  • Experience with high-throughput (HTP) nucleic acid purification and liquid handling (Ex. Firefly)
  • Experience running HTP gel electrophoresis units (Ex. Agilent Tape Station)
  • Self-motivated, flexible, proactive, works well under pressure and deadlines, detail-oriented
  • Enthusiastic to learn new skills and take on new responsibilities
  • Creative problem-solver who can perform technical trouble-shooting
  • Communicates clearly and proactively to ensure data delivery to stakeholders

Preferred Experience:

  • Experience operating sequencing platforms (Ex. Illumina MiSeq, NextSeq2000)
  • Comfortable with Illumina’s Basespace and data transfer
  • Experience in library preparation for NGS (genotyping), WGS, mRNA-seq, single cell-seq, ATAC-seq, and rhAMP-seq applications.

Education and Experience:

  • BA/BS with 1+ years of hands-on research in bioengineering, molecular biology, genetics or related fields, such as computational biology

What Colossal Offers You:

  • Medical, dental, and vision coverage
  • Unlimited PTO and company holidays so you can rest and recharge
  • Flexible spending accounts (FSA)
  • Company matched 401k retirement plan
  • Paid parental leave up to 12 weeks
  • Education reimbursement
  • An opportunity to help us return the Earth to a healthier state

The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.

Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.

Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.

EEO is the Law

Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.

Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:

  • #1 on the 50 Best Startups to Work For in Dallas in 2023!
  • 100 Best Midsize Places to Work in Dallas in 2024 & 2025
  • 100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 & 2025

Built In 2025 Award Lists

Great Place to Work Certification Page

Most Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.

Newsweek's Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!